近日，下一代精准医疗小分子新药研发公司Allorion Therapeutics 安锐生物医药有限公司（下称“安锐生物”）宣布完成5000万美元B轮融资。本轮融资由启明创投共同领投。

至此，安锐生物已经获得国际国内多家知名投资机构的鼎力支持。自2020年7月成立以来，公司累计融资超过1亿美元。

本轮融资将主要用于支持安锐生物的两个小分子新药项目的I/II期临床研究（中美两地），以及管线中的其它高潜力项目。安锐生物同时也将继续深耕已经得到验证的两大平台：系统性变构抑制剂筛选平台及合成致死靶点和分子筛选平台，完成更多针对难成药靶点药物的验证性筛选。本轮融资的资金也将帮助安锐生物进一步搭建国际水准的临床开发团队和商务拓展团队。

伴随安锐生物B轮融资的完成，有着超过30年新药开发经验的临床研究专家Dr. Gregory Berk正式加入公司出任首席医学官（Chief Medical Officer），全面负责搭建中美两地的临床团队，以及在中国和美国即将开展的I/II期临床研究。Dr. Berk曾任美国多家知名生物技术和生物医药公司的临床高级副总裁和首席医学官，在抗肿瘤新药临床研究领域有非常丰富的经验和临床KOL资源。Dr. Berk的加入将使得安锐生物迅速搭建临床研究阶段生物医药公司所需的能力和资源，实现为患者带来可解决未满足的临床需求的新药和提升公司价值两重目标。

对于公司成功完成B轮融资，安锐生物共同创始人兼首席执行官丁强表示：“我们衷心感谢新老投资方对安锐生物的肯定和大力支持。自公司成立以来，安锐生物已经在美国波士顿和中国广州都建立了研发实验室，并且拥有由50余名全职员工组成的强大研发团队。短短两年半时间，公司通过团队的共同努力和高效率地研发，已经将两个项目推进到中美IND申报阶段，同时公司高度创新的技术平台也在不断产生更多有巨大临床需求和商业价值的全球新小分子项目，有的已经推进到临床候选分子选择阶段。安锐生物也在积极和多家国际药企讨论合作开发，多个管线在今年的摩根大通医疗健康年会（J.P. Morgan Healthcare Conference）上引起广泛的合作兴趣，体现了国际药企对安锐生物创新的认可。我们将充分利用团队和资金优势，继续保持以科学和数据为基础的研发策略，全力以赴推进临床研究，来满足未满足的临床需求，造福病人。”

启明创投合伙人陈侃表示：“安锐生物团队由来自诺华、默沙东、礼来等知名生物制药公司的行业老兵组成，具有丰富的小分子药物研发经验。在成立的两年时间里，安锐生物成功开发出两款候选药物分子并推进到临床阶段，验证了公司的变构抑制剂和合成致死药物筛选平台，展现了团队优秀的执行力。我们非常期待这些管线的临床数据，也期待着公司的技术平台能够产生更多的优质候选化合物，达成更多的国内外商务合作，通过不断的产品和技术创新，为人类的生命健康事业创造价值。”

本轮融资由渶策资本和启明创投共同领投，泰福资本、江远投资、三生制药集团、Octagon Capital、骊宸资本跟投。

Allorion Therapeutics, a next-generation precision medicine company focusing on oncology and autoimmune diseases, raises $50 million Series B financing

Allorion Therapeutics ("Allorion"), a biotech company focusing on next-generation precision medicine for oncology and autoimmune diseases, announces the completion of a $50 million Series B financing round, co-led by Qiming Venture Partners. Since its establishment in July 2020, Allorion has raised over $100 million from reputable institutional biotech investors.

The funds raised in this round will primarily support upcoming Phase I/II clinical trials in both China and the U.S. and the identification of clinical candidates for additional programs. Allorion will also continue to advance its established and validated early discovery platform technologies, including an allosteric inhibitor screening platform and a platform for discovery of synthetic lethality targets and molecules. The funds will also enable Allorion to further build world leading clinical development and business development teams.

As the Series B financing round concludes, Dr. Gregory Berk has officially joined Allorion as the Chief Medical Officer (CMO). Dr. Berk is a clinical research expert with over 30 years of experience in novel drug development. He will be responsible for building clinical teams in the U.S. and China, as well as designing and overseeing the Phase I/II clinical trials in both countries. Before joining Allorion, Dr. Berk held senior management positions as SVP or CMO at several renowned biotech/biopharma companies in the U.S., including Abraxis BioScience, Intellikine, BIND BioSciences, Sideris Pharmaceuticals, and GT Biopharma. His extensive clinical trial experience and industry network will help Allorion transition from preclinical research to the clinical development stage, developing new drugs to address significant unmet medical needs while creating value for the company.

Regarding the successful Series B financing, Peter Ding, Allorion's co-founder and CEO commented, "We sincerely appreciate the recognition of and support from both new and existing investors who participated in this round of financing. Since its launch in July 2020, Allorion has established wet labs in both Boston and Guangzhou, and currently has a strong R&D team of more than 50 full-time employees. In just two and a half years, the company has advanced two small molecules to IND stage in both China and the U.S. Our highly innovative technology platforms have generated first-in-class small molecule programs with immense clinical and commercial value, some of which have progressed to the clinical candidate selection stage. Allorion is also actively pursuing collaboration and co-development opportunities with several global pharma companies, who have shown great interest in our programs at this year's JPM conference, demonstrating a global recognition of our innovation. Upholding a science- and data-driven R&D strategy, we will continue to fully leverage our team's capabilities, platforms, and funds to advance clinical development and address unmet medical needs for patients."

Kan Chen, Partner at Qiming Venture Partners commented, "Allorion team consists of industry veterans from well-known biopharmaceutical companies such as Novartis, Merck, and Eli Lilly, who boast rich experience in small molecule drug discovery. The team has advanced two molecules to the clinical stage and verified the company's allosteric inhibitor and synthetic lethality screening platforms, demonstrating its strong execution capability. We are very much looking forward to the clinical data, additional high-quality drug candidates generated by the company's technology platforms, and its collaboration with international and Chinese pharma, driving more innovations valuable to human health."

INCE Capital and Qiming Venture Partners co-led the financing, with participation from TF Capital, Long River Investment (LRI), 3SBio Group, Octagon Capital, and Elikon Venture.

关于启明创投

启明创投成立于2006年，先后在上海、北京、苏州、香港，西雅图、波士顿和旧金山湾区设立办公室。

目前，启明创投旗下管理11只美元基金，7只人民币基金，已募管理资产总额达到94亿美元。自成立至今，专注于投资科技及消费(Technology and Consumer, T&C)、医疗健康(Healthcare)等行业早期和成长期的优秀企业。

截至目前，启明创投已投资超过480家高速成长的创新企业，其中有超过180家分别在美国纽交所、纳斯达克，香港交易所，上交所及深交所等交易所上市，及合并等退出，有70多家企业成为行业公认的独角兽和超级独角兽企业。

启明创投投资企业中，很多已经成长为各自领域中最具影响力的公司，包括小米集团 (01810.HK) 、美团 (03690.HK) 、哔哩哔哩 (NASDAQ:BILI, 09626.HK) 、知乎（NYSE:ZH, 02390.HK）、石头科技 (688169.SH) 、甘李药业 (603087.SH) 、泰格医药 (300347.SZ, 03347.HK） 、再鼎医药 (NASDAQ:ZLAB, 09688.HK) 、康希诺生物 (688185.SH, 06185.HK) 、Schrödinger (NASDAQ:SDGR) 、惠泰医疗 (688617.SH) 、诺辉健康(06606.HK)、启明医疗 (02500.HK) 、三友医疗 (688085.SH) 、艾德生物 (300685.SZ) 、贝瑞基因 (000710.SZ) 、神州细胞 (688520.SH) 、圆心科技、康缔亚、信念医药、文远知行、壁仞科技、优必选等。